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Reproductive Psychiatry Foe: Depakote

Updated: Jan 13

One of the very few medications we avoid in reproductive psychiatry is Depakote or Valproic Acid. It is a really great mood stabilizer medication, so don’t fret if you have to take it, but make sure to be on birth control (probably a barrier contraception too) and folic acid if you are a woman of reproductive age. That said, the rate of neural tube defects in babies exposed to Depakote is really high, about 1 in 50 to 1 in 100 (1-2%).


Depakote is a treatment option for bipolar disorder, migraines and seizures.


Posts are for education only. Please consult your healthcare provider before making any changes to your treatment plan.



Pregnant woman lying on a bed with a colorful plaid blanket, hand gently resting on her belly, wearing a white tank top and gray shorts.





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